There are various causes of foot blisters, including friction, athlete’s foot, sweat herpes, etc. Antifungal ointment, hormonal ointment, immunosuppressant ointment, etc. need to be selected according to the cause of the disease for treatment. Foot blisters caused by friction do not require special medication, wear appropriate shoes and socks, and avoid squeezing and friction in the near future. Foot blisters caused by tinea pedis need antifungal treatment, topical drugs include clotrimazole, ketoconazole, terbinafine, butenafine, amorphophine, cyclopamine, etc., and need to adhere to the standardized use of long-term medication, so as to avoid recurrence. Foot blisters caused by sweating herpes can be treated with topical glucocorticoid ointment such as hydrocortisone cream, immunosuppressant ointment such as tacrolimus ointment and pimecrolimus ointment. There may be other reasons for the blisters on the feet, it is recommended to consult a doctor in time, symptomatic treatment. All of the above medications should be used under the guidance of a medical professional and should not be treated blindly.