I. What are the commonly used embolic agents for liver cancer interventional therapy? What are their advantages and disadvantages? In China, the commonly used embolic agents for liver cancer interventional therapy include menthol sponge, iodized oil, PVA granules, microspheres and drug-loaded microspheres. Generally speaking, all kinds of embolic agents are effective, but the objective efficiency of drug-loaded microspheres is better than other embolic agents, and it has less side effects. Its disadvantage is that it is more expensive, with a market price of around 30,000 dollars. Moreover, it requires a high level of skill and experience in embolization, and the applicator needs to be specially trained. Objective effective rate: it refers to the % of the necrotic part of the lesion after embolization. Why should hepatic artery embolization (intervention) be combined with other methods? For what kind of patients? The so-called “applicable” means that the patient can improve the survival or quality of life after treatment Interventional therapy is a local treatment, in order to control the growth of local lesions, it is necessary to cooperate with a variety of methods of combined treatment. For example, embolization + radiofrequency ablation, etc. However, the tumor is a systemic disease with potential metastasis, so it needs to be combined with systemic therapy to prevent metastasis, including antiviral therapy, immunotherapy, molecular targeting therapy, etc. What kinds of liver cancer can be used in the treatment of liver cancer by combining hepatic artery embolization with radiofrequency? In Barcelona staging, it belongs to: 1) stage A (inoperable patients); 2) some patients in stage B (about 5cm in diameter, single lesion); 3) small residual lesions after embolization; 4) What kind of hepatocellular carcinoma can be used in interventional liver cancer and combined with cryopreservation? Unless multiple treatments are performed, since the cryoprobe has a smaller treatment range at one time, it is generally used to treat liver cancer lesions with smaller diameters or lesions in certain areas, such as hepatic margin lesions. V. What kinds of liver cancer treatments can liver cancer intervention combined with microwave be used for? Basically, the indications are the same as those of radiofrequency ablation treatment, single lesion with diameter around 5cm. VI. Should intervention be done before radiofrequency and cryotherapy, or radiofrequency and cryotherapy first, and then intervention? Can it be done at the same time? Effective ablation therapy (radiofrequency, cryotherapy) is when the treatment boundary exceeds the tumor boundary by 5mm~10mm, which is called the safety boundary. Ablation therapy after embolization reduces blood flow to carry away heat and improves the efficiency of ablation therapy. Generally, the effect of embolization is evaluated before deciding whether to combine ablation therapy; because complete necrosis of the lesion after embolization does not require ablation therapy; if the residual lesion after embolization is very large, it is not suitable for ablation therapy; sometimes the residual lesion after embolization is in a certain direction of the main lesion, and the ablation therapy must be clear before the target can be treated. VI. If I have had radiofrequency or cryotherapy before, can I still have intervention after a period of time? Who can’t? Depends on whether there are residual lesions after MRI enhancement and whether there are tumor trophoblastic vessels available for embolization by CTA.