Erectile dysfunction (ED for short) refers to a man’s inability to obtain proper hardness or sufficient erection time during coitus, thus not being able to have a satisfactory sex life, resulting in disturbances in the couple’s life and often secondary to serious psychological disorders. Due to its unique privacy, the exact incidence is difficult to obtain, but with the accelerated pace of social life and the increased pressure of people’s daily work and life, the incidence is on an increasing trend, seriously affecting people’s physical and mental health and jeopardizing the harmony and happiness of the family. It is estimated that about 50% or so of men have experienced erectile dysfunction at some point in their lives. The development of modern civilized society, the expansion of all kinds of knowledge and information, the intensification of the sense of competition and urbanized life, people’s unlimited pursuit of material life, all of them have a huge impact on people’s physical and mental, and men are born with a strong sense of dominance in the social and family life, making them more likely to become the victims of these factors; coupled with smoking, excessive alcohol consumption, eating irregularly or irrationally ( In addition, smoking, excessive alcohol consumption, irregular or irrational eating (excessive intake of spicy, stimulating, greasy food), irregular work and rest and lack of necessary exercise may have a huge negative impact on men’s physical and mental health, and become the triggers of ED. Therefore, in modern society, men’s self-adjustment of their own physical and mental health, good at resolving all kinds of conflicts and pressure, and as far as possible to give up all kinds of bad habits have become the first condition for the prevention and treatment of ED. The birth of PDE5 inhibitors has become a milestone in the treatment of ED. Since the introduction of Viagra, this little blue pill has made the treatment of ED easy, reliable and safe. At present, in addition to Viagra, there are also two types of dosage forms, Alida and Cialis, which can play a good therapeutic role in almost all functional ED and nearly half of the organic ED. However, in the course of diagnosis and treatment, we often find that numerous patients lack the necessary understanding of the drug’s effects, adverse reactions and methods of administration, thus affecting its efficacy. Here, I would like to focus on a few common clinical problems in order to help patients using this drug. First, the mechanism of action of all PDE5 inhibitors is to induce erection by affecting the activity of nitric oxide and phosphodiesterase locally in the penile corpus cavernosum, causing relaxation of penile corpus cavernosum smooth muscle and filling of penile corpus cavernosum blood vessels, so they do not contain any hormones. Even if you take it for a long time, it will not cause adverse effects on the human endocrine. Secondly, the use of Viagra should be appropriate half to one hour before intercourse, but some people statistically even 3-4 or even 5-6 hours after taking it, it still works well. Third, before taking, it is best not to drink and eat too much greasy food; after eating, it is best to wait for 3-4 hours after the stomach food is properly digested and emptied to take will play a better effect. Fourth, after taking the medicine, there must be appropriate sexual stimulation (preferably coitus) to induce a good erection; without sexual stimulation, the penis will not be naturally erect. Fifthly, patients often ask whether the medication can achieve a cure? Does it need to be taken for life? To this question, I believe that the efficacy of the treatment varies from person to person according to the specific conditions of each person and the severity of the disease. I realize that for mild to moderate and even some severe patients, as long as they follow a reasonable course of treatment, it is not impossible to achieve a cure for ED. Of course, this process requires a certain amount of time and enough patience, and it is unrealistic to expect that good results can be achieved in a relatively short period of time or 2-3 tablets. In short, as long as doctors and patients work closely with each other and establish a good atmosphere of mutual trust and communication, the treatment of ED will get good results. I wish every ED patient to get rid of the disease soon! Wish every couple has a healthy and pleasurable sex life!