Lao Mei is 40 years old this year, although his work is very good, but in the past 10 years due to the penis can not get an erection, the male that aspect of the function is gradually lost. As a man in that area can not, so he felt in front of others can not raise their heads, during which also took many kinds of drugs, looking for many private specialized hospitals, but the effect is very poor, the original happy family is also facing a rupture. “I was desperate, I had no confidence in my future, for a long time I was struggling between life and death”, said Lao Mei. This is the inner struggle of a long-time erectile dysfunction patient, and is also a common voice of other patients with similar conditions. With the rapid socio-economic development and increasing pressure of life, the number of men with erectile dysfunction (ED) is increasing year by year and has become an important factor affecting men’s work life and family harmony. The causes of ED are simply divided into three categories: 1. Psychological ED: caused by physiological changes in the nervous system, this type of ED is also known as functional ED. the penis can not be erected during sex, or can be erected during excitement, and then soften when entering the vagina. In the past, it was believed that most of the ED is psychological ED, accounting for more than 90%, but now it is believed that it accounts for 50%-70% of ED. Recent studies have shown that no matter what kind of ED, there are different degrees of psychological factors. 2, organic ED: due to organic factors, the performance of the penis at any time can not be erect or erection. Including vascular ED, neurological ED, endocrine ED, accounting for 30%-50% of ED. 3, mixed ED: refers to psychological and organic factors caused by the inability to get an erection or erectile dysfunction. With the further development of clinical research, more and more patients belong to mixed ED. The treatment of ED should be based on the principle of effective, safe and convenient, so that sexual life can be carried out in a natural state without interference. According to the consensus reached by global experts, the options for ED treatment include: general treatment: as far as possible to remove the factors that cause ED, such as smoking, alcoholism, staying up all night, and psychosexual disorders, etc., in our country, Chinese medicine treatment also occupies a certain position; first-line treatment: oral drug therapy, that is, the PDE5 inhibitors; second-line treatment: intracorporeal injection of vasoactive drugs, urethral drug delivery, vacuum negative compression narrowing device, etc. Third-line treatment: surgical treatment, including penile prosthesis implantation and revascularization surgery. The choice of treatment program needs to be based on the doctor’s clinical experience, patient compliance and post-treatment visits. We have found that most patients prefer to receive medication, and global experts recommend choosing non-traumatizing medication first, while the long-term effects of second- and third-line treatments are yet to be seen. At the same time, we also found that after the above diagnosis and treatment, there are still a considerable number of patients with ineffective treatment or poor results. This requires an individualized treatment plan based on the patient’s specific situation. For example, small dosages of medication, adequate sexual stimulation, and rehabilitation. Our experience, for example, with a longer half-life of tadalafil, for example, 10mg each time, every other day, each time after taking the drug 3-4 hours to consider sexual life (at this time the highest concentration of the drug, the effect is most ideal); if there is no fixed sexual partner patients, can be 36 hours after taking the drug, through other sexual stimulation, to promote penile erection, 10-15 minutes each time, once every 6-8 hours; if the effect is not satisfactory, can be increased to 20 mg of tadalafil, the drug can be increased to 20mg of tadalafil. Satisfactory, can be increased to 20mg every other day, or 10mg taken daily, can achieve the ideal sustained drug concentration. Like the old plum such as long years of treatment ineffective patients in about 12 weeks -24 weeks of systematic rehabilitation training, and now only need to 5mg tadalafil on-demand or even without taking the drug, can be very good to complete the sex life. When he came for follow-up, he could proudly say it in front of many patients, “The treatment effect is very good, even better than before, I really didn’t expect that I can still recover my sexual life!” Individualized treatment of ED is the hot spot of current research, and also brings new hope for the majority of ED patients.