Many melasma spots on the face can be improved by medication and physical therapy, and patients should follow the doctor’s instructions for treatment. Melasma is a yellow-brown pigmentation spot on the face, which is common in young and middle-aged women. The cause of chloasma is not yet completely clear, but genetic susceptibility, ultraviolet radiation and sex hormone level changes are important factors, and other drugs, cosmetics or diseases may also lead to the occurrence of chloasma. 1. Drug treatment: patients can follow the doctor’s instruction to use hydroquinone and its glycoside derivatives externally, including hydroquinone cream, arbutin and so on. Patients can also take vitamin C, vitamin E, tranexamic acid, glutathione and other drugs orally for treatment. Combined treatment can be considered to enhance the efficacy if necessary. 2. Physical therapy: laser therapy, such as intense pulsed light, Q laser, picosecond laser and so on. Through the selective photothermal effect of laser, it destroys the pigment particles to achieve the purpose of treating chloasma. It is necessary to go to the hospital for consultation and take medication or other treatments under the guidance of the doctor.