Globulin is secreted by the body’s plasma cells and has an immune protective effect against foreign invading pathogenic microorganisms, which is beneficial to the organism, but also has a side that triggers autoimmune diseases and is detrimental to the organism. I. The main causes of high globulin: 1, liver disease: seen in patients with chronic viral hepatitis, autoimmune liver disease, drug-related liver damage and various causes of cirrhosis, liver cancer; 2, infectious diseases: chronic infections of viruses, bacteria or parasites, such as schistosomiasis, tuberculosis, black fever, chronic Q fever, etc., can stimulate the body’s immune system and produce antibodies, resulting in elevated globulin 3, autoimmune diseases: such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis, dermatomyositis, etc., often manifest as elevated immunoglobulins; 4, hematological system diseases: such as multiple myeloma, plasma cell disease, lymphoma, macroglobulinemia, etc.; 5, other: acute dehydration situation caused by high fever, vomiting, diarrhea, sweating, etc., can cause the body’s plasma concentration, which will show The performance of high globulin. The main hazards of high globulin: 1. secondary infections: for example, macroglobulinemia, manifested by significantly elevated IgM, but IgM function is abnormal, can not exercise immune protection, easy to secondary bacterial and other pathogenic microbial infections; 2. cause disease relapse: high globulin may cause the relapse or aggravation of autoimmune diseases. Because high globulin indicates the persistence of abnormal antibodies, antigen and antibody immune complexes can trigger the disease again; 3, formation of blood clots: high globulin can lead to increased blood viscosity and easy formation of blood clots.