The common causes of acne on both sides of the cheeks include bacterial infection, exuberant secretion of androgen, and medication factors. According to the cause, pay attention to facial cleanliness, and give the corresponding drug treatment. 1. Bacterial infection: should be timely anti-infection treatment, oral metronidazole or roxithromycin and other drugs. 2. Androgen secretion: usually pay attention to do facial skin cleaning work, if necessary, can be appropriate application of some such as ethyl estradiol tablets, estradiol tablets and so on with anti-androgen effect of the drug. 3. Drug factors: such as long-term oral dexamethasone or hydrocortisone and other drugs, generally do not need special treatment, after stopping the drug will be relieved. If you have acne on both sides of your cheeks, it is recommended that you go to the hospital in time and follow the doctor’s instructions for treatment.