If you do not drink a lot of alcohol, have no previous allergic reactions to alcohol or are not allergic to durian, eating a small amount of durian after drinking alcohol usually does not have serious adverse effects, but the situation needs to be closely monitored. However, if there is a previous allergic reaction to alcohol or an overdose of durian, there are adverse reactions to eating durian after drinking. First, there are obvious gastrointestinal reactions, such as nausea, vomiting, bloating, diarrhea, watery stools or pain around the umbilicus. Second, allergic-like reactions, such as skin redness, swelling, heat, pain, rash, rash, papule, rash, rash or even vesicles, oozing, etc. Third, severe allergic reactions to durian after drinking can lead to adverse reactions such as chest tightness, shortness of breath, difficulty breathing and transient loss of consciousness.