Night blindness is considered to be caused by normal vision in the daytime and blindness in the evening or after entering a dark room. There are many causes of night blindness, but retinitis pigmentosa is common in clinical practice. In this group of patients, night blindness gradually appears in the early stages of the disease, because retinitis pigmentosa is caused by abnormal function of photoreceptors, and most patients have more severe involvement of the optic rod cells, so the patient’s dark vision is significantly impaired. A fundus examination will reveal typical retinal osteoblast-like pigment changes, for which there is no effective treatment. There are also other causes of night blindness, such as corneal achromatopsia due to vitamin A deficiency, congenital anisometropia, and advanced glaucoma.