What is the best medication for diabetic foot? What kind of antibiotics can I use to control the infection that is never under control? Although I have said that the use of antibiotics for treating wound infections in diabetic patients is permitted, there are requirements for their use and only the right ones are the most appropriate and have the maximum effect. Today we will take a look at what antibiotics are generally chosen for first-time patients who have not yet had time to debride their wounds. First of all, for patients with grade 1 and 2 in diabetic foot grading, which are generally mild infections, still in good nutritional status, and who have not yet applied antibiotics before admission, their infections tend to be more common with Staphylococcus aureus and Streptococcus lactis, etc. Penicillins can be the first choice in this case. For patients with serious conditions such as grade 3, 4 and 5, with osteomyelitis, often caused by acute illness or prolonged delay in treatment, these patients are admitted with low hemoglobin and albumin levels, and their infections are often more common with gram-negative bacilli, so aminoglycosides (such as amikacin and gentamicin), third-generation cephalosporins (such as ceftazidime) and carbapenems (such as imipenem) can be chosen. Of course, all of the above are empirical treatments for patients who have just been admitted to the hospital and have not yet received insulin therapy. Before the report of bacterial culture and drug sensitivity is available, it is necessary to empirically administer drugs after a comprehensive assessment of the infection in combination with the patient’s clinical manifestations, biochemical indicators, imaging examinations, etc. At the same time, samples should be taken for bacterial culture and drug sensitivity test in a timely manner, and after the corresponding results are obtained, appropriate sensitive antibiotics should be selected to control the infection. Moreover, the culture and drug sensitivity should be done regularly at a later stage, because the structure of the flora may change after a period of treatment, and the antibiotics must be adjusted according to the patient’s condition in a timely manner, and should be discontinued if necessary. Another point is that in addition to antibiotics to control the infection, it is also necessary to choose the right time to debride the wound according to the patient’s own situation. If the wound is not debrided, the inflammatory tissue on the surface of the wound is still heavily loaded with germs, and experience has shown us that it is difficult to control the infection even with high doses or a combination of antibiotics, while it is much easier after debridement. Of course, in addition to the use of antibiotics, there are other drugs for the wound itself, for example, there are many kinds of Chinese herbal oils, ointments and bulking agents in the combined Chinese and Western medicine treatment method, which can maximize the effect according to the different periods of the wound and the purpose of treatment. In short, there is no best medicine, only suitable and appropriate. If you use the right one, you can cure the disease, but if you don’t use the right one, it will become more and more serious and cause irreparable damage to the patient.