Histopathologic examination of the skin lesions in some patients with atypical clinical presentation is helpful in confirming the diagnosis in the skin examination of facial clefts. The epidermal stratum corneum of the facial cleft lesion has the characteristic changes of hyperkeratosis and hyperkeratosis, proliferation of keratinocytes, prolongation of dermal papillae, capillary hyperplasia, and a small amount of lymphocyte infiltration around the lesion, and histopathological examination of the lesion can help to confirm the diagnosis. Skin examination methods for facial clefts are described as follows: 1. X-ray examination: X-ray examination (fluoroscopy, radiography, etc.) is needed to clarify the location, type and degree of joint damage, as well as the comparison after treatment. Infected patients should also undergo chest radiography to understand the specific situation. 2, skin biopsy: mainly to check the skin biopsy cells belong to the dermal protrusion neatly prolonged and the lower part of the thickening, dermal papilla prolongation and edema, granular layer disappears, keratinization is not complete, MUNRO microabscess state. Facial clefts in the epidermis, skin biopsy of patients with facial clefts can be derived from the type of skin lesions in patients with facial clefts suitable for the use of what kind of topical drugs for treatment. 3, trace element examination: trace elements is the body to maintain normal activities of the important substances, trace elements once the lack of normal human body in the edge of the disease state. In addition, the level of trace elements can also show whether the human body is in an abnormal state.