La water refers to diarrhea, colchicine after eating has been diarrhea can follow the doctor’s instructions to adjust the dose of the drug or stop taking, may be appropriate amount of rehydration, if necessary, under the guidance of a doctor to take antidiarrheal drugs, etc. (such as montelukast). Some patients have persistent diarrhea after taking colchicine may be related to the adverse effects of the drug, usually patients can follow the doctor’s advice to reduce the dose of colchicine, or stop taking. Since persistent diarrhea is prone to cause water-electrolyte disorders and blood volume insufficiency, appropriate amount of rehydration can be used to prevent accidents such as hypovolemic shock. For those with severe diarrhea, antidiarrheal drugs such as montelukast, loperamide hydrochloride, etc. can be taken as prescribed by the doctor. Colchicine has the effect of inhibiting the chemotaxis, adhesion and phagocytosis of neutral leukocytes; it can inhibit phospholipase A2, reduce the release of prostaglandins and leukotrienes from monocytes and neutral leukocytes; it can inhibit the production of interleukin-6 by the local cells, so as to achieve the control of pain, swelling and inflammation in the local joints. Colchicine is indicated for the treatment of acute attacks of gouty arthritis and prevention of acute attacks of recurrent gouty arthritis. It is prone to cause adverse reactions such as vomiting and diarrhea. It is contraindicated in people with hypomelanosis, renal or hepatic insufficiency. Precautions: If vomiting, diarrhea and other reactions occur, the dosage should be reduced, and in serious cases, the drug should be stopped immediately. It is recommended that patients use the drug under the guidance of a doctor, do not use the drug or increase or decrease the dosage on your own, in order to avoid adverse consequences.