Skin manifestations of uremia patients are skin pallor, itching, dryness, flaking and hyperpigmentation, and if combined with coagulation dysfunction at the same time, skin hemorrhages and petechiae may also appear. In uremia, there are symptoms and organ damage related to uremia as a result of decreased renal excretion and metabolic function, accumulation of uremic toxins, and endocrine dysfunction of the kidneys. Clinical manifestations of uremia can occur in various organs and systems of the body, such as cardiovascular, respiratory, digestive, blood system and skin, etc. The skin manifestations of patients with uremia are mainly in the form of ecchymosis and ecchymosis. Skin manifestations of uremia patients are mainly pale, itchy, dry, flaky and hyperpigmented; due to the combination of platelet dysfunction, or the use of anticoagulants, patients with uremia may have skin bleeding spots, petechiae and other manifestations. In addition, patients with uremia are often accompanied by shortness of breath, dyspnea, inability to lie down, pulmonary edema and other cardiovascular and respiratory manifestations; loss of appetite, nausea, vomiting, gastrointestinal bleeding and other gastrointestinal manifestations; indifference, delirium, convulsions, sensory neurological disorders and other neurological manifestations, and so on. If uremia is diagnosed, it is necessary to go to the hospital in time for regular treatment to effectively treat the primary disease and remove the factors that lead to further deterioration of renal function, so as to avoid further development of the disease.