Localized blistering after treatment with photorejuvenation is mostly due to localized thermal burns caused by inappropriate energy or improper operation. In terms of treatment, firstly, we should strengthen skin care, secondly, according to the size of the blisters, we can take puncture drainage treatment, and when there are clear signs of infection, we must combine antibiotic treatment. 1. Strengthen skin care: photorejuvenation treatment immediately after the blisters can be immediately iced to reduce local oozing. Keep the affected skin clean, avoid excessive scratching and stimulation, and keep the integrity of the blister wall. 2. Puncture drainage treatment: for small blisters, generally do not need to carry out too much treatment. When the size of the blister is large, a sterile needle can be used to puncture and drain the fluid in the low position of the blister. The puncture process must pay attention to the aseptic operation. 3. Antibiotic treatment: When there is obvious redness or signs of infection in the local skin, anti-inflammatory drugs must be combined, such as topical complex iodine solution, mupirocin ointment, and so on. Another can be used externally growth factor gel to promote wound repair. Photorejuvenation treatment blisters must be timely to the regular medical institutions, the specific circumstances need to ask the doctor to interview and then choose the appropriate way to deal with.