The time for HPV18 infection to turn negative varies and is determined by several factors, including the duration of infection, the amount of viral load and the immunity of the patient, all of which are combined to determine the time to turn negative. If the viral load is low, the duration of infection is short, and the patient’s immunity is strong, the patient will be able to turn negative naturally within 3-6 months. However, if one of the three factors is significantly dominant, the infection takes a relatively long time to clear. Women of childbearing age can generally show a natural regression of the virus in 70-80% of them. Only if the infection is longer, with a persistent high-risk viral infection for more than 5-10 years, the risk of getting cervical cancer is greatly increased.