The cause of dark stools needs to be clarified before considering whether to treat with medication and determining the specific medication. If the cause is physiological, no medication is needed; if the cause is pathologic, drugs such as omeprazole, teprenone, entecavir, etc., and other treatments such as interventional surgery, traditional surgery, radiotherapy and so on, may be needed. 1. Physiological causes: such as taking iron, bismuth and other drugs; such as consuming animal blood products, animal liver and other foods, can cause black stools, usually do not need medication. 2. Pathological causes: common diseases include peptic ulcer, cirrhosis, esophageal and gastric tumors. If peptic ulcer can be treated with drugs such as omeprazole, teprenone, domperidone, etc.; if liver cirrhosis can be treated with drugs such as entecavir, glutathione, etc.; if esophagogastric fundal varices may require interventional surgery; if esophageal and gastric tumors may require traditional surgery. For patients with dark stools, it is recommended to go to the hospital in time to clarify the cause before considering specific treatment measures. Medications should be used under the guidance of a doctor.