Pain in the hand during infusion is generally caused by the following common reasons and treatment methods: i. Due to the poor vascular elasticity of the patient, leakage during infusion can cause obvious bulging at the infusion site, which can cause local pain in the patient at this time. This can be done by replacing the infusion site and applying topical 50% magnesium sulfate and four yellow hydromel ointment locally to the swollen site to promote the decreasing of the swollen tissue and reduce the pain symptoms. Second, the patient input liquid too fast or infusion of liquid irritation, too high concentration, can also cause pain in the hand. For example, when infusing potassium chloride solution and fatty milk solution, the liquid can cause obvious pain because of its strong irritation to blood vessels. In this case, the painful symptoms of the hand can be reduced by diluting the input fluid, slowing down the infusion speed or changing to central vein for infusion.