The normal index of chitosanase should be <79ng/ml. chitosanase is known as chitosanase 3-like protein 1, abbreviation is CHI3L1, is a kind of secretory glycoprotein, >134ng/ml suggests cirrhosis, 79-134ng/ml suggests significant liver fibrosis. 1. Clinical significance is that it is a marker of liver fibrosis and cirrhosis caused by hepatitis B, hepatitis C, alcoholic hepatitis, schistosomiasis and non-alcoholic fatty liver disease, and a tracking indicator of the effect of antiviral treatment. 2. It is suitable for the diagnosis and treatment of liver fibrosis and cirrhosis caused by viral, alcoholic, pharmacological and immune factors, etc.; the grading of liver fibrosis and cirrhosis; the dynamic monitoring index of antiviral and antifibrotic treatment; and the examination index for early screening of liver fibrosis and cirrhosis. If there is any discomfort, it is recommended that patients go to regular hospitals for consultation and treatment, and should not blindly treat themselves in order to avoid delaying their condition.