Lymphangioleiomyomata in children are common congenital vascular malformations that can occur anywhere in the body, but are more common in the head, neck, and axillae. Lymphangioleiomyomata in children usually do not fade on their own and increase in size as the child grows. 65-75% of lymphangioleiomyomata are detected at birth. During infancy, lymphatic duct malformations around the floor of the mouth and throat can lead to respiratory obstruction, esophageal obstruction and dysphonia, which can be life-threatening if not treated properly. Some children are combined with recurrent intracapsular hemorrhage or infection; leading to megalingualism and jaw hypertrophy. Minimally invasive interventional sclerotherapy is used to reduce the production of lymphatic fluid and shrink the cystic lumen by damaging the endothelial cells of the cystic lumen with chemical agents, producing sterile inflammation and promoting the proliferation of local fibroblasts and collagen fibers, and scar formation around the lymphatic duct malformation. Minimally invasive interventional sclerotherapy for lymphangioleiomyomatosis in children is a less invasive, simple, safe and reliable method.