If there are granules in the vagina, the most common clinical condition is caused by genital condyloma acuminatum. This condition often has a history of high-risk sexual activity or multiple sexual partners and is transmitted to the sexual partner after sexual contact. It is also a good idea to use laser treatment. If the vagina feels granular by hand, but sometimes it is often formed by normal vaginal folds, because women of childbearing age have many folds in the vagina under the effect of estrogen, which are not smooth by hand, and the vagina is particularly stretchy, it is recommended to have a detailed gynecological examination to understand whether it is a physiological or pathological condition.