A typical case: Wang, a female, 42 years old, felt morning nausea, belching and upper abdominal discomfort 3 months ago, which could be slightly relieved after eating. When she came to the hospital, the doctor suggested gastroscopy, but the patient was afraid of the examination and worried that she would not tolerate it, so she refused to undergo the examination and repeatedly asked for some gastric medicine first. After taking the medicine for a month, the symptoms were significantly reduced and even disappeared. However, after half a month, the above symptoms recurred and were accompanied by loss of appetite and vomiting several times. Finally, he was determined to undergo a gastroscopy. It was found that there was a huge ulcer in the corner of the stomach, about 2.5X3.0cm in size, which was biopsied as a low-differentiated adenocarcinoma, and the chance of radical surgery was lost. Don’t be afraid of gastroscopy Cases like Ms. Wang’s are often encountered in hospital outpatient clinics. Many people think that gastric disease is not a disease, so as long as they pay attention to their meals and eat their medicine, they will be fine and do not care much. There are also many patients who are afraid of gastroscopy and are reluctant to undergo it. Although doctors repeatedly mobilize, think it is a big deal, some have prescribed gastroscopy checklist many times, but once in the examination room again hesitant. The doctor had no choice but to note in the medical record that “patient refused gastroscopy”. Gastroscopy is the most direct means of diagnosing esophageal gastroduodenal diseases, and for patients with complex conditions, heavy symptoms, or inconspicuous results after treatment, only early examination can lead to early diagnosis and treatment, otherwise it is very easy to delay the timing of treatment. Gastroscopy is important In fact, gastroscopy is a routine examination through which different lesions such as esophageal gastroduodenal ulcers, inflammation, tumors and polyps can be detected, and it is currently the most direct examination method that cannot be replaced. In Japan, gastroscopy has been introduced as a health check-up once every two years. Therefore, the detection rate of early gastric cancer in Japan is very high, and the treatment effect is also very good, and often a cure can be achieved, and cancer is no longer a very terrible disease. In China, many patients are already in the middle and late stages when they find out gastric cancer and lose the time for treatment, which brings great losses to families and individuals. With the development of science and technology and the update and improvement of gastroscopy equipment, the pain caused by gastroscopy is now less and less, and the level of diagnosing diseases has been significantly improved. Therefore, there is no need to be overly nervous, worried and fearful. Nowadays, the gastroscopy tube is not only soft and thin, but also the doctor’s operation level has been improved significantly, so as long as the patient cooperates, the gastroscopy can be completed quickly. In addition, painless gastroscopy is also commonly used in clinical practice, which can greatly reduce the patient’s pain and eliminate fear. People over 40 years of age should undergo gastroscopy screening once a year. Patients with family history of gastric cancer, suffering from chronic atrophic gastritis, gastric polyps, and gastric mucosal intestinalization without any change in their condition should also preferably undergo regular gastroscopy for early follow-up judgment of the condition, early detection, and timely and reasonable effective therapeutic intervention.