Ototoxic drugs are drugs that cause serious side effects on the auditory nerve, which can lead to neurological tinnitus, neurological deafness, and even memory loss, hearing loss, vertigo, etc. if applied for a long time. Usually the most common drugs with ototoxicity are streptomycin, gentamicin, and neomycin. Now gentamicin has been from one generation to four generations, and the toxicity and nephrotoxicity are gradually reduced, but it has not been completely able to play a role in eliminating the side effects of ototoxicity. Anti-tumor drugs such as vincristine and cisplatin have been shown to have ototoxic side effects, and anti-platelet aggregation drugs, such as aspirin and Bactrim, have occasionally been shown to cause hearing damage due to ototoxic reactions. However, the ototoxicity of these drugs is usually transient and will be relieved after drinking large amounts of water.