The consequences of long-term application of hormone creams are as follows: 1. Dermatitis: Long-term application of hormone creams can trigger glucocorticoid-dependent dermatitis in the skin, especially in the face, which can cause epidermal thinning and capillary dilation, making the skin abnormally sensitive, and can also cause inflammatory skin reactions, including skin flushing, swelling, papules and pustules, and the skin may have itching, tightness, burning sensation and pins and needles. 2. 3. Hormonal side effects: Long-term application of glucocorticoid ointment in large quantities will lead to a series of hormonal side effects, including obesity and damage to other organs. Therefore, hormone ointment should be used moderately according to the condition, not just for a long time and in large quantities, to avoid a series of side reactions caused by long-term application.