Urticaria is the scientific name for urticaria. The cause of urticaria is complex and most patients cannot find a specific cause. Although it is difficult to find the cause of the disease, we should try to find the cause and remove it in order to help patients heal. For patients with a clear cause or a suspected cause, etiologic treatment can be carried out to avoid inhalation, contact and ingestion of as many triggering substances as possible. The choice of medication is mainly based on symptomatic treatment, especially for chronic urticaria, because urticaria can easily recur. Therefore, when choosing medication, it is important to choose safe, effective and convenient medication, and at the same time to tell the patient the principle of regular medication, and to improve the quality of life of the patient as the goal. The drug selection of the second generation of antihistamines, commonly used are loratadine tablets, levocetirizine hydrochloride tablets, and olopatadine hydrochloride tablets, etc. The course of treatment for patients with acute urticaria should be more than 14 days, while patients with chronic urticaria need to take 1-3 months, and if the effect of eating an antihistamine is not good, 2 can be applied in combination.