Macrotesticular disease may be caused by inflammatory infection, testicular effusion or testicular tumor, which is mainly treated with anti-infective therapy, surgery, radiotherapy and so on. 1. Inflammatory infections: testicular enlargement may be caused by testicular inflammation, mostly due to bacterial infections, which can be treated with cephalosporin or quinolone antibiotics, such as cefadroxil, cephradine, levofloxacin, norfloxacin and so on. 2. Testicular effusion: when there is a large amount of fluid in the testicle, it is also easy to cause testicular enlargement, which can be relieved by testicular sheath reversal surgery. 3. Testicular tumor: including benign and malignant tumors, if it is benign tumors that cause megalobladder, it can be directly removed by surgery. If it is caused by malignant tumor, it usually needs to take surgical resection, radiotherapy and chemotherapy according to the situation. Giant testis may also be caused by other reasons, it is recommended that patients go to the hospital in a timely manner, cooperate with the doctor to do the relevant examination, after clarifying the cause, targeted treatment treatment.