Pruritus is a self-reported symptom common to many skin conditions. Pruritus is diagnosed if there is only itchy skin without significant primary skin damage. Systemic pruritus is mostly associated with medical diseases. For example, neurasthenia, diabetes mellitus, menstrual disease, anemia, leukemia, nephritis, and constipation can cause pruritus. External causes are mainly related to external stimuli, dry skin in the winter cold and sweaty skin in the summer heat. Wearing chemical fiber woolen fabrics, using too strong alkaline soap, topical drugs and contact with various chemicals can all contribute to the occurrence of the disease. Atrophic sebaceous glands and sweat glands secretion function is reduced, causing dry skin, is the causative factor of systemic pruritus. Treatment can be internal, combined with external use. Internally administered drugs include antihistamines, vitamin C, calcium, sodium thiosulfate, and sedative-hypnotics, which can be chosen specifically according to the condition. In severe generalized pruritus, intravenous closure with procaine hydrochloride or oral dexamethasone and prednisolone can be applied. Aged generalized pruritus can be treated with sex hormones. Acupuncture, decoction of Chinese herbs for external washing, and physical therapy are also mostly used in clinical practice.