Under normal circumstances, intracellular and extracellular calcium ion concentration is maintained in dynamic balance. Modern medical research has found that when the intracellular calcium ion concentration continues to increase, causing cellular excitation-contraction uncoupling, it will lead to hypertension, myocardial infarction, heart failure, sudden death and other diseases, recently called intracellular “calcium deposition” or “calcium in-flow Calcium intraluminal flow” is a recent term for intracellular calcium deposition. Calcium deposition is a disease that occurs when insoluble calcium salts are deposited in tissues. They are classified as idiopathic, metastatic and dystrophic. Idiopathic calciphylaxis is often of unknown cause, and metastatic calciphylaxis is secondary to disorders of calcium and phosphorus metabolism, such as hyperparathyroidism, multiple myeloma, and renal insufficiency with phosphate retention. Dystrophic calcinosis is most often secondary to skin or tissue injury. Most patients are idiopathic or secondary to localized tissue damage; a few are familial and metabolic. Examples include hypercalcemia and hyperphosphatemia, vitamin D toxicity, diabetic renal dialysis, concomitant connective tissue disease and other crystalline deposition diseases. Most people with calcific deposits in tendons can be asymptomatic, with their histologic calcifications appearing as concentrated granular or caseous material. Severe pain occurs only when the deposits increase in size and compress or trauma and the bursa ruptures, causing inflammation. Inflammatory adhesions to the bursa from calcified deposits can also be present, causing pain, limitation of movement, and systemic symptoms.