Sacubitril is a drug for the treatment of heart failure, there is no best drug for heart failure patients, to choose the most appropriate medicine. Sacubitril belongs to the enkephalinase inhibitors, can increase the production of endogenous brain natriuretic peptide in the body, play the role of vasodilator, diuretic and so on, is an effective drug for the treatment of heart failure. For heart failure patients, there is no best drug, only the most appropriate drug. Sacubitril has a certain effect on heart failure, but simply taking this drug orally is not effective in controlling heart failure, it also needs to be combined with other drugs, such as diuretics, beta-blockers, vasodilator drugs, etc., in order to better control blood clots. Adverse effects of Sacubitril include angioedema, headache and dizziness, hypotension, etc. It is contraindicated in women who are allergic to the drug components, have severe renal impairment, or are pregnant. Sacubitril is a commonly used drug for the treatment of heart failure, and should be used under the guidance of a physician to choose the right indications.