Raynaud’s disease, also known as Raynaud’s syndrome, is a spastic disease of the small arteries of the extremities caused by the sympathetic nerve dysfunction that innervates the peripheral blood vessels. It is a syndrome in which spasm of small arteries in the extremities causes a series of skin color changes in the hands or feet. Traditionally, Raynaud’s symptoms are divided into two types: 1, primary, that is, Raynaud’s disease, can not find any underlying disease and the symptoms and remission of the disease. 2, secondary, also known as Raynaud’s phenomenon with one or more diseases, the symptoms and course of the disease is more serious. At present, Raynaud’s disease and Raynaud’s phenomenon have been combined, collectively referred to as Raynaud’s syndrome. The following patient is a finger blood collection after the needles appear necrosis, with a history of Raynaud’s disease, treatment room attention to insulation, to prevent further deterioration of the disease, to prevent infection.