The use of cephalosporin antibiotics after drinking alcohol can lead to intoxication-like symptoms, which is mainly due to the fact that cephalosporin inhibits the metabolism of alcohol in the body, leading to the accumulation of alcohol in the body and poisoning. The principle of cephalosporin inhibition of alcohol metabolism is due to the conversion of alcohol into acetaldehyde under the action of ethanol dehydrogenase in the body, which is then hydrolyzed into acetic acid and water under the action of acetaldehyde dehydrogenase and finally excreted from the body. Cephalosporins inhibit the activity of acetaldehyde dehydrogenase, so that acetaldehyde cannot continue to be metabolized after drinking, resulting in a large accumulation of acetaldehyde in the body, and the drunkenness-like symptoms that appear after drinking, such as redness and redness, are caused by the accumulation of acetaldehyde in the body. Therefore, it is prohibited to use cephalosporin after drinking to prevent cephalosporin from inhibiting the metabolism of alcohol, which may lead to drunkenness-like symptoms.