The various types of puli antihypertensive drugs have different structures, different half-lives and methods of administration, and different metabolic pathways. Generic drugs refer to angiotensin-converting enzyme inhibitors, including captopril, enalapril, benazepril, fosinopril, etc. Although they all belong to the same class of drugs, there are certain differences in the chemical structure of the drugs, which have sulfhydryl, carboxyl and phosphonyl groups as their core groups respectively, resulting in certain differences in the duration of action of the drugs and the method of dosing. For example, Captopril is a short-acting drug with a half-life of about 3 hours, and needs to be taken 3 times a day to ensure stable efficacy. Enalapril’s half-life can reach 11 hours, some patients can take the drug once a day, and those with serious conditions need to take it twice a day. The half-life of Benadryl can reach 11~12 hours, most patients can take the drug once a day, and the dose can be increased for poor control. In addition, the metabolic pathways are different; captopril, enalapril, and benadryl are mainly metabolized through the kidneys, while fosinopril is metabolized through dual channels in the liver and kidneys. The adverse reactions of Puli drugs are similar, mostly dry cough, edema, nausea, vomiting, dyspnea, dizziness, etc. Allergy to drug components, bilateral renal artery stenosis, severe renal impairment and other patients are prohibited, so the use of medication must be carried out under the guidance of a professional physician.