To determine the duodenal ulcer has been healed can be judged from the clinical manifestations, examination and other ways, but the clinical manifestations may not be accurate, need to be combined with gastroscopy. 1. Clinical manifestations: duodenal ulcer patients may have hunger pains or night pains in the abdominal pain, can also be accompanied by decreased appetite, acid reflux, belching and other symptoms, if the duodenal ulcer related clinical manifestations in the treatment did not reappear, it means that the patient’s condition may be improved, or even cured, but need to be combined with the gastroscopy examination, further clarification. 2. Examination: patients diagnosed with duodenal ulcer can undergo gastroscopy again, under the gastroscope to observe whether the ulcer surface is healing, if healing is suggestive of healing; accompanied by Helicobacter pylori infection should be rechecked Helicobacter pylori, if after treatment there is no Helicobacter pylori infection also suggests that the patient’s condition has improved, or even healed. Patients diagnosed with duodenal ulcer are advised to actively cooperate with the doctor for treatment, and need regular review after treatment if necessary.