The causes of swollen and painful toes are trauma, nail groove inflammation, gouty arthritis, tenosynovitis, etc. The causes are different, and the treatments are also different, and the commonly used medications are non-steroidal analgesic drugs, antibiotics, and so on. 1. Trauma: due to violence or heavy objects smashed toes, there may be local soft tissue injury, or even toe bone fracture, should promptly consult a doctor for examination, and follow the doctor’s instructions for oral non-steroidal drugs such as diclofenac sodium, meloxicam, etc., to relieve local pain. 2. Inguinitis: Inguinitis can be caused by toe trauma, ingrown nails and other factors, causing swelling and pain in the toes, which should be promptly sterilized and changed, and antibiotic ointment such as mupirocin cream and fusidic acid cream should be applied locally. 3. Gouty arthritis: a disease triggered by the deposition of urate crystals in the joints, resulting in redness, swelling, pain and other symptoms of the toes, you can take oral non-steroidal anti-inflammatory drugs such as ibuprofen, loxoprofen, etc., specialist treatment of gouty drugs, such as colchicine, benzene bromelain, etc., and actively lower the uric acid treatment. 4. Tenosynovitis: the tendon sheath is jammed or edematous due to too frequent activities, resulting in swelling and pain in the toes, you can take oral non-steroidal anti-inflammatory drugs such as ibuprofen, diclofenac sodium, etc., to play an anti-inflammatory and analgesic role. If the patient has swollen and painful toes, it is recommended that the patient go to the hospital in time to clarify the cause of the disease and give targeted treatment. The above medications should be used under the guidance of a doctor.