In China, a more extensive population ALT screening was conducted in the 1960s, and asymptomatic elevated serum ALT accounted for about 5-10% of the population. After the development of HBsAg testing, it was found that the detection rate of HBsAg was three times higher in those with abnormal ALT than in those with normal, and nearly half of those with elevated single ALT were hepatitis B without xanthogranuloma. So what are the pathogenesis of single alt elevation? Let’s take a look at them together. It is generally believed that mono-alt elevation has “three slow” characteristics: slow onset, slow recovery, and slow progression. Under adverse conditions, hepatitis without jaundice can also be transformed into jaundice, which is related to the amount of virus, the strength of virulence and the level of immunity or resistance of the body. This jaundice occurs in single alt elevation mainly because the hepatitis virus invades the liver and replicates in the liver cells. Under the action of the body’s immune response, together they damage the hepatocytes, causing edema and destruction of hepatocytes so that liver tissue undergoes a series of changes such as inflammatory infiltration, congestion, edema, exudation, hepatocyte degeneration and necrosis. This affects the normal state and structure of liver tissues and damages various functions of bilirubin metabolism in the liver, so that bilirubin cannot be discharged normally from the biliary system and enters the blood, and bilirubin runs with the blood to all organs of the body, then all organs can be dyed yellow. Single alt elevation is also divided into the acute phase, as well as the chronic phase. Patients should pay attention to rest and avoid exertion in the process of receiving treatment, otherwise it will aggravate the disease, in addition, patients should pay attention to nutritional supplementation, it is recommended to eat more high-calorie, high-protein food, of course, the diet structure needs to be balanced.