Calcium channel blockers, also called calcium antagonists, are one of the antihypertensive drugs and can be divided into dihydropyridines and non-dihydropyridines according to the molecular structure and action of the drugs. Dihydropyridines include the frequently used nifedipine, which is the representative of dihydropyridines, and non-dihydropyridines include verapamil and diltiazem. Calcium channel blockers can be divided into two categories, short-acting and long-acting, according to the duration of the drug. Short-acting is nifedipine, diltiazem, etc. Long-acting can be divided into amlodipine, lacidipine, lercanidipine, and felodipine extended-release tablets, nifedipine controlled-release tablets, etc. Calcium channel blockers can reduce the resistance of the blood vessels, reduce renal tubular sodium reabsorption, and rapid onset of action, antihypertensive efficacy is stronger, and the magnitude is also stronger. For the metabolism of blood lipids and blood glucose, there is no significant effect, and the ability and compliance of long-term blood pressure control is better, especially for the elderly, it has a better antihypertensive effect. Long-term application of calcium blockers also has an anti-atherosclerotic effect. There are very few individuals who may experience side effects. The side effects include rapid heartbeat, facial flushing, headache, and lower limb edema.