Itching and red papules on the skin after sweating are usually considered to be caused by cholinergic urticaria, which is mainly manifested as small, extremely itchy, punctate clusters. The main cause of cholinergic urticaria is an increase in body temperature due to exercise, high temperatures, mood swings, or after drinking hot food or alcohol, which stimulates the sweat glands innervated by the cholinergic sympathetic nerves to produce sweat, and the rash appears after the release of acetylcholine from the cholinergic nerve impulses of the parasympathetic nervous system. The main symptoms of cholinergic urticaria include small bumps and red papules with itching, etc. In severe cases, symptoms may include palpitations, headache, abdominal pain, and shortness of breath. Mild forms of cholinergic urticaria fade quickly or have itchy skin but no skin damage and are easily overlooked. Cholinergic urticaria is usually treated symptomatically, mainly with medication, to control the patient’s symptoms and improve the quality of life. Oral antihistamines such as fexofenadine, loratadine, epastine, imipramine, cetirizine and levocetirizine can be taken, and topical drugs such as glyburide lotion and benadryl can also be used, which have an anti-itching effect.