The author used a combination of Chinese and Western medicine to treat the hematological system damage of systemic lupus erythematosus (SLE) from April 2008 to April 2010, and achieved good results, which are reported below. 1. Clinical data The observed cases were patients in the rheumatology department of our hospital, and all of them met the diagnostic criteria of SLE revised by the American Rheumatism Association in 1982 [1] and the relevant identification criteria of the qi and blood deficiency type in the Guidelines for Clinical Research on New Chinese Medicines (for trial implementation) [2]; and were accompanied by the manifestation of blood routine abnormalities (hemoglobin < 110 g/L, white blood cells < 4.0×109/L, platelets < 100× 109/L in one or more of them). There were 61 cases, 7 males and 54 females; age 21-58 years, with more aged 30-50 years; clinical manifestations were mainly pallor, fatigue, sweating and fear of cold, palpitations and insomnia, dizziness and tinnitus, hypochondria, shortness of breath, lumbar and knee weakness or lumbago, low menstrual volume and color, or amenorrhea, thin tongue with thin coating, thin and weak pulse. 2.Treatment Prednisone treatment, 40mg per day, morning dose, for 2 months. No other western medicine was taken during the course of medication, and the dose was reduced by 5mg every 2 weeks according to the improvement of symptoms and laboratory tests, and maintained at 20mg. In addition, the prescription of the formula is: Astragalus membranaceus 45g, Paeonia lactiflora 30g, Radix Rehmanniae 24g, Cornu Cervi Pantotrichum 18g, Radix et Rhizoma Sangyang, Poria, Zedoaria, Dampi 15g each, Radix Angelicae Sinensis, Radix et Rhizoma Glycyrrhiza Uralensis 12g each. if the skin mucous membrane erythema is obvious, add Comfrey, Diyu 18g each. 1 dose per day, decocted twice with water, extract 400mL of juice, take 200mL each in the morning and evening, and observe the efficacy for 2 months. 3. Observation indexes ①Symptoms and signs: The clinical manifestations such as weakness, palpitations and shortness of breath were recorded in a uniform form before medication, and recorded once a week until the end of the course of treatment. ②Blood routine: from the beginning of the experiment, blood leukocytes, hemoglobin and platelets were checked and recorded once every 2 weeks until the end of the course of treatment. 4. Efficacy criteria and treatment results 4.1 Efficacy criteria Refer to the Guidelines for Clinical Research on New Chinese Medicines (for trial implementation) [2] formulated. Clinical remission: the main symptoms disappeared after treatment, and blood leukocytes, hemoglobin and platelets returned to normal. Effective: the main symptoms improve, blood leukocytes, hemoglobin and platelets tend to be normal. Effective: The main symptoms improved, blood leukocytes, hemoglobin and platelets increased. Ineffective: No improvement in symptoms, signs and laboratory tests after treatment. 4.2 Treatment results: 48 cases in clinical remission, 6 cases with significant effect, 2 cases with effective effect, and 5 cases with ineffective effect. 5. Discussion The incidence of hematologic damage in SLE patients is generally 50% to 70%, and a few patients have hematologic lesions as the first manifestation, mainly manifesting as anemia, leukopenia, and thrombocytopenia. At present, the cause of blood cell reduction in each lineage is not well understood, and most scholars believe that the decrease in blood cells is related to autoantibodies. Treatment is mostly with glucocorticoids, together with immunosuppressants and biological agents, which can achieve better results in patients in the acute stage. However, it is clinically found that Western medicine treatment mostly treats the symptoms but injures the root cause, and most of the drugs have toxic side effects, which can easily lead to other complications, resulting in endocrine disorders, producing bone marrow suppression, reversible or irreversible damage to the reproductive system, aggravating rash, hair loss, and blood cell reduction, etc. Therefore, in the stable stage of SLE patients, it is recommended to combine Chinese and Western medicine therapy, mainly using prednisone treatment, together with Chinese medicine evidence-based treatment, without affecting The type and amount of western medicine should be gradually reduced on the basis of the comprehensive therapeutic effect. SLE hematologic damage is mostly due to deficiency of Qi and blood and deficiency of kidney essence in Chinese medicine. Prednisone is still used clinically as the drug of choice for treatment, and at the same time, the prescriptions used to benefit qi and nourish blood, invigorate blood and tonify kidney also play an important role. According to Chinese medicine, the pathogenesis of the disease is due to congenital deficiency, overexertion and injury caused by diet and emotion, resulting in deficiency of the five organs and loss of essence, especially the spleen and kidneys, and at the same time, water-dampness, stasis and toxicity. In this case, we should keep in mind the deficiency of Qi and Blood as the main pathogenic mechanism, and at the same time take into account the water-dampness, stasis and toxicity, and give this formula to benefit Qi, tonify the kidney and invigorate Blood. This formula is composed of three parties: Danggui tonifying the Blood, Liuwei Dihuang Wan, and Shao Yao Gan Cao Tang. The formula is composed of three parties: Angelica Sinensis Tonic Blood Soup, Liu Wei Di Huang Wan and Paeonia Lactiflora Glycyrrhizae Tang. Liu Wei Di Huang Wan contains three tonics and three drains, which not only benefits the kidney but also drains turbidity, filling the essence without retaining evil, and filling the kidney essence is beneficial to the mutual transformation of essence and blood. Paeonia lactiflora and Glycyrrhiza glabra soup, sour and sweet to transform yin, is supplemented by Cornu Cervi Pantotrichum sour to strengthen yin. The whole formula works together to benefit Qi and nourish Blood, tonify Kidney and fill essence, invigorate Blood and drain turbidity.