With the continuous improvement of medical rescue methods and the development of intensive care technology, many patients with cranial trauma, cerebrovascular accidents, such as “cerebral hemorrhage”, “massive cerebral infarction”, or ischemic-hypoxic encephalopathy caused by respiratory and cardiac arrest are brought back from the edge of death. Patients with ischemic-hypoxic encephalopathy caused by respiratory and cardiac arrest are brought back from the brink of death, but become “vegetative”, which is medically called a vegetative state. Can these vegetative patients come to their senses? How do they come to their senses step by step? Can they return to normal life or even to work? A large number of clinical studies and statistical data analysis found that after timely and active treatment, a considerable number of “vegetative people” can come to their senses. 50% of post-traumatic vegetative state can regain consciousness, while 15% of non-traumatic vegetative state can also regain consciousness. Here we should mention the concept of “minimal consciousness”, which is the pathway from the vegetative state to wakefulness, and is the bridge between the vegetative state and the recovery of consciousness. Entering the minimally conscious state is the first step to enter the door of awakening, which indicates that the patient is moving in a good direction and that the doctor and the patient’s family should have a positive attitude and adopt a timely and correct coma promotion program to treat the patient, so that the patient can have a chance to wake up and return to the family and society. The three steps of coma promotion process: coma vegetative state – minimal consciousness state. Let’s take a look at the three-step process of waking up a comatose patient: Coma – Vegetative State – Minimal Consciousness. Step 1: Coma is a state of mental unresponsiveness that cannot be awakened. It is a very serious disorder of consciousness in which the state of wakefulness and the content of consciousness as well as somatic movements are completely lost; the patient is in a state of unresponsiveness to external stimuli and cannot be awakened to recognize himself and his surroundings, and the patient’s eyes are closed and the sleep-wake cycle is lost. This state is usually seen by family members in the intensive care unit, with the patient’s eyes closed, motionless, and unresponsive to any call or push. Coma is usually short-lived, because of the progress of medical treatment technology, through more active rescue treatment, most patients can survive, began to open their eyes, but still can not understand the words, which entered the vegetative state, or we say “vegetative”. Step 2: Our national definition of vegetative state is: 1. loss of cognitive function, no conscious activity, unable to carry out instructions; 2. ability to open eyes automatically or under stimulation; 3. sleep-wake cycle; 4. purposeful eye tracking movement; 5. inability to understand and express language; 6. maintenance of voluntary respiration and blood pressure; 7. basic preservation of subthalamic and brainstem functions. Patients with traumatic vegetative state have a disease duration of more than one year, and the possibility of recovery becomes smaller. Therefore, the comprehensive treatment at this stage is especially important. This stage can be treated with a series of treatments such as neuromodulation electrical stimulation, transcranial magnetic stimulation, transcranial direct current stimulation, right median nerve stimulation, acupuncture and physiotherapy, rehabilitation functional exercise, Chinese herbal medicine assistance, hyperbaric oxygen, nutritional support, music therapy, sensory stimulation therapy, passive motor therapy and drug impact wake-up therapy. After treatment, if the patient’s consciousness improves further, he or she enters the minimally conscious state. Step 3: The diagnosis of minimal consciousness must be based on the repeated or persistent presence of one or more of the following behaviors to demonstrate limited but clear cognitive ability of self and surroundings: Following simple commands Answering yes or no with posture or language regardless of correctness Understandable language Purposeful behavior, including incidental movements and emotional responses related to environmental stimuli, not involuntary movements spontaneous actions. For the difficult to detect minimal consciousness, we will also assist with clinical tests such as EEG, MRI, pet-CT, etc., mainly to better clarify at which level of consciousness. Both this stage and the neuromodulation electrical stimulation placed in the previous stage will play a great role in promoting awakening. It will improve the blood supply to the brain, reduce the ischemic area, activate the cholinergic reticular upstream agonist system, and at the same time excite the various functional areas of the cerebral cortex, so that the various islands of the brain that have lost contact with each other can be reconnected to achieve the effect of reawakening the patient. The effect is to reawaken the patient and enable him/her to re-integrate into normal social life. Neuromodulation therapy plays an increasingly important role in the treatment process, aiming to activate the brain’s consciousness network and promote the patient’s wakefulness. Waking up from a coma is a long process that tests the perseverance of the patient, the patience of the patient’s family, and the skill of the doctor. We should pay great attention to the minimal state of consciousness, which is a necessary path to awakening. Whether we enter this state from the vegetative state or are already in this state, we have to race against time and use appropriate treatment to give the patient a higher starting point for awakening.