Liver disease has no clinical evidence to indicate which specific part of the body will be itchy, itchy symptoms may be limited to a certain part of the body such as itchy skin, but also may be accompanied by the whole body, or may not appear itchy symptoms. Liver disease includes hepatitis, cirrhosis, liver cancer and other diseases, usually caused by viral infections, fatty liver, immune system disorders and other factors. When bilirubin is elevated above a certain range, cholestasis can be accompanied by localized or generalized itching of the skin, which may recur. After the bilirubin drops to the normal range, the itching symptoms can be relieved. If itching symptoms persist and cannot be relieved, you should go to the hospital immediately and take oral medication such as aluminum hydroxide and stellate ganglion block therapy under the guidance of a medical professional.