Intercostal neuralgia can take glutamine and vitamin B1, there is a certain role in the treatment, at the same time, should promptly seek medical attention to identify the cause of the disease, for the cause of the treatment. Intercostal neuralgia, also known as intercostal neuritis, often occurs in mechanical injury, thoracic spine degeneration, thoracic spine injury, viral infection, ankylosing spondylitis, or mediastinal pleural lesions, tumors, etc., resulting in intercostal nerve compression, irritation, inflammatory reaction, pain. If it is just simple nerve pain, glutamine and vitamin B1 have the effect of nourishing the nerves, but they cannot be used to relieve nerve pain, and medications such as gabapentin and pregabalin are needed to relieve nerve pain. If there are other causes, etiologic treatments should be performed, such as antiviral, anti-infection, and surgery. Intercostal neuralgia should be treated promptly.