Spironolactone is a diuretic, which in principle has a potassium-conserving and sodium-removing effect, so potassium supplementation is not routinely required. However, it needs to be decided according to the patient’s own blood potassium situation, and if it is itself a potassium deficiency state, potassium supplementation therapy is required during the oral administration of spironolactone. For example, the most common disease of the urinary system is primary aldosteronism syndrome, which can cause severe hypokalemia and can be treated with spironolactone. Its main purpose is to prevent excessive loss of potassium from the urine so that the patient’s blood potassium does not become too low. This condition requires concurrent potassium supplementation therapy, regular monitoring of blood potassium changes, and then aggressive surgical treatment. If the treatment is only to improve edema, spironolactone is needed and no potassium supplementation therapy is routinely required, as well as regular monitoring of blood pressure concentrations. Spironolactone is often combined with other types of diuretic drugs in synergistic therapy, such as combining with furosemide tablets for treatment. The two can both diuretic and potassium conserving, so that hypokalemia does not occur and therefore potassium supplementation therapy is not required. However, in the case of specific disease conditions where there is hypokalemia, potassium supplementation is required.