Cryptogenic opportunistic pneumonia requires treatment with glucocorticoids and anti-infective therapy for those with infection. Cryptogenic pneumonia is a kind of interstitial pneumonia with a large number of lymphocytic infiltration in the alveolar septa and proliferation of type II alveolar epithelial cells at the lesions, so its treatment is based on glucocorticosteroids, such as prednisone and prednisone acetate, etc. Glucocorticosteroids help to control the disease rapidly and prevent the emergence of respiratory failure and so on. Glucocorticoid treatment usually takes more than 6 months to prevent recurrence of the disease. In some cases of cryptogenic opportunistic pneumonia combined with infectious pneumonia, antibiotic anti-infective treatment such as azithromycin, cefixime, etc. can be used. Patients with cryptogenic opportunistic pneumonia need to consult a doctor in a timely manner, under the guidance of the doctor’s formal treatment, and should not use their own medication arbitrarily.