The differences between small cell carcinoma and large cell carcinoma include: different types, different sites, different shapes of cancer cells, different components in cell plasma, different time of metastasis and different treatment methods. 1. Different types: large cell carcinoma includes large cell neuroendocrine carcinoma, basal cell carcinoma, clear cell carcinoma and so on. Small cell carcinoma includes oat cell type, intermediate cell type and compound oat cell type. 2. Different sites of occurrence: large cell carcinoma can occur in the bronchial tubes near the lung doors or at the edge of the lungs. Small cell carcinoma has metastasized to hilar and mediastinal lymph nodes in early stage. 3. Different shapes of cancer cells: large cell carcinoma cells are large, but their sizes are different, and they are often polygonal or irregular. Small cell carcinoma is mostly round or diamond-shaped. 4. Different cytoplasmic components: large cell carcinoma has abundant cytoplasm, which can be divided into giant cell type and clear cell type, while small cell carcinoma contains neuroendocrine particles in cytoplasm. 5. The time of metastasis is different: large cell carcinoma metastasizes later. Small cell carcinoma mostly has extrapulmonary metastasis at the time of diagnosis. 6. Different treatment methods: large cell carcinoma treatment includes radiotherapy, chemotherapy, gene test, targeted therapy, etc. Small cell carcinoma treatment includes chemotherapy. The treatment of small cell cancer includes chemotherapy and radiotherapy. Normally, one should develop good living habits, not smoking, quit smoking as early as possible, eat more fresh vegetables and fruits, and have regular medical checkups (it is recommended that people over 35 years old should have a medical checkup once a year). If there are any uncomfortable symptoms such as cough, bloody sputum or hemoptysis, fever, unexplained weight loss, etc., it is recommended to go to regular hospitals for consultation in time.