The main causes of newborn pimples on the face include the following: first, the symptoms caused by inflammation of the hair follicles of newborns. If the newborn’s hair follicles are infected with bacteria, it will cause inflammation of the hair follicles resulting in small pimples on the face, which can be applied topically with Bactrim or Lincomycin Lidocaine gel. Secondly, acne is caused by acne in newborns. As the hormone levels of newborns are not the same after birth and in the mother’s womb, the fluctuating hormone levels in newborns lead to endocrine disruption and fluctuating hormone levels, which can lead to small pimples on the face of newborns, and most of them can subside on their own as they get older without special treatment.