1. Is colon cancer prone to brain metastasis? Colon cancer takes the second place among female cancers and the third place among male cancers. Brain metastasis of colon cancer often occurs after the diagnosis of colon cancer, and about 10%-15% have brain metastasis when colon cancer is diagnosed. 2. What are the characteristics of brain metastasis of colon cancer? Brain metastasis from colon cancer occurs in 35%~55% in the posterior cranial fossa, which is significantly higher than the brain metastasis from other cancers. The number of brain metastases from low colon cancer and rectal cancer (draining into the portal system and inferior vena cava) is significantly higher than that from high colon cancer (draining into the portal system). 3. Is the prognosis of brain metastasis from colon cancer good? With active treatment, the 5-year survival rate of patients with brain metastases from colon cancer exceeds 60% after diagnosis, which is one of the types of brain metastases with the best treatment effect, so they should be treated actively. 4. What are the manifestations of colon cancer brain metastasis? The most common symptoms of brain metastasis from colon cancer are headache, weakness, cognitive and behavioral impairment, seizures and ataxia. Therefore, patients with a history of colon cancer should seek neurosurgery consultation as soon as the above symptoms appear. 5. Is carcinoembryonic antigen (CEA) reliable for the diagnosis of brain metastasis of colon cancer? Although carcinoembryonic antigen (CEA) can be used as a reliable marker for screening colon cancer, its diagnostic value for brain metastasis of colon cancer is not definite yet. 6. What tests should be done to confirm the diagnosis when brain metastasis of colon cancer is suspected? For patients with brain metastasis of kidney cancer, it is better to do enhanced cranial MRI examination. Head CT examination can be used as primary screening, and enhanced CT examination can be done for patients who cannot undergo MRI examination. 7. How should brain metastasis of colon cancer be treated? Brain metastasis of colon cancer is mainly treated by surgery and radiotherapy, and the role of chemotherapy is very limited. (1) Surgery is to obtain the main treatment specimen to clarify the pathological diagnosis, control the metastases locally, and relieve the occupying effect caused by the metastases and their peritumoral edema. Cerebrospinal fluid shunt surgery can also be considered for certain difficult to resect posterior cranial fossa tumors causing hydrocephalus. (2) Radiotherapy alone has poor prognosis, while surgery combined with whole brain radiotherapy significantly prolongs the survival of patients. (3) Chemotherapy Although chemotherapy is effective for primary foci of colon cancer, it has no definite effect on brain metastases of colon cancer.