There is no single examination in the world that can provide the only reliable localization information. The main methods to explore the lesion include: the manifestation of the patient’s discovery process; examination of anatomical structures (e.g. CT, MRI, etc.); electrophysiological examination (various types of EEG and magnetoencephalography); and nuclear medicine examination (SPET, PET, etc.). Doctors should choose various examinations reasonably according to the type of occurrence and the financial affordability of the patient. Generally speaking, if multiple examination means suggest the same localization information, the results are more reliable, among which electrophysiological examination results are dominant, and currently there are mainly long-range video EEG, 128-conductor dipole localization EEG, intracranial implantation electrode EEG, etc.