The three highs refer to high blood lipids, high blood pressure and high blood sugar, and there are more causes for the three highs. For example, it is caused by heredity, underlying diseases, drugs and so on. 1. Hypertension: it can be divided into two categories: primary and secondary. The cause of primary hypertension is not clear at present, and secondary hypertension is mostly caused by certain identified diseases with elevated blood pressure. For example, glomerulonephritis. The increase in angiotensin causes small arteries to contract and peripheral resistance to increase, causing hypertension. 2. Hyperlipidemia: It is divided into primary dyslipidemia and secondary dyslipidemia. Primary dyslipidemia may be related to environmental factors and heredity. Secondary dyslipidemia is mostly caused by diseases, drugs and other factors. For example, hypothyroidism, diabetes, spironolactone and so on. 3. Hyperglycemia: there are physiological increase and pathological increase, in addition to physiological factors, the disorder of glucose metabolism caused by genetic factors, tumors, stress factors, drug factors, etc. are pathological hyperglycemia. When the three highs are accompanied by discomfort, one should consult a doctor in time, follow the doctor’s instructions for further examination, and carry out targeted treatment or therapy with the help of the doctor.