There is no absolute quick relief for headache. The main painkillers used for headache are non-steroidal anti-inflammatory drugs (NSAIDs), ergot preparations, treprostinil, opioid preparations and so on. 1. Non-steroidal anti-inflammatory drugs: such as ibuprofen, acetaminophen and so on. They are generally used to treat migraine, tension headache, etc. 2. Ergot-type preparations: such as ergotamine, dihydroergotamine and so on. They are specific drugs for migraine and can effectively inhibit acute attacks of migraine. 3. Triptans: such as Sumatriptan, Naratriptan and so on. Although this type of drug has a good pain relief effect, but the vasoconstriction effect is relatively strong, high blood pressure, heart disease patients should be used with caution. 4. Opioid preparations: such as pethidine. Suitable for acute attacks of severe headache, but addictive, need to pay attention to the use of drugs. Headache may also be caused by other diseases, need to actively treat the original disease. It is recommended that patients seek timely medical attention to clarify the cause, standardize treatment, and strictly follow the doctor’s instructions for the use of medication.