Glutamyl transpeptidase generally refers to glutamyl transpeptidase. High glutamyl transpeptidase may indicate liver problems, caused by pathologic factors, normal physiological phenomena, or drug factors. 1. Pathological factors: Glutamyl transpeptidase is a normal substance in human body, which is involved in amino acid metabolism and widely distributed in human kidney, pancreas and liver, among which it is mainly distributed in the cytoplasm of hepatocytes and epithelial cells of intrahepatic bile ducts. When patients have chronic viral hepatitis, alcoholic hepatitis, fatty liver, cirrhosis and other diseases, glutamyl transferase will be high. 2. Normal physiological phenomenon: If the patient has fatigue, staying up late, irregular eating habits, drinking a lot of alcohol before the examination, glutamyl transpeptidase may appear physiological elevation. 3. Drug factors: non-steroidal anti-inflammatory drugs such as ibuprofen, or statin drugs such as simvastatin, etc., may also cause liver function damage, which is manifested in high glutamyl transpeptidase. It is recommended that patients with high glutamyl transpeptidase should consult a doctor in a timely manner and take standardized treatment under the guidance of the doctor, and do not take medication on their own to avoid delaying their condition.