Dry cracked lips and blisters may be caused by lipitis, herpes on the lips and mouth and other diseases, should be clearly diagnosed, choose the appropriate treatment, including drug treatment, general treatment and so on. 1. Lipitis: If lipitis leads to dry cracked lips and blisters, clinically based on local symptomatic treatment, patients can use local ointment such as gentamycin ophthalmic ointment treatment can also drink more water to supplement vitamins for observation. If the effect of local treatment is not good, you can follow the doctor’s instructions oral prednisone and other glucocorticoid therapy, combined with vitamin A to reduce the lip mucous membrane flaking, vitamin B to promote mucous membrane growth. Remove the triggers during treatment to avoid aggravation of symptoms. 2. Oral and lip herpes: dry and cracked lips blisters may also be caused by oral and lip herpes, the treatment is based on antiviral, pain relief, etc., the patient can follow the doctor’s instructions to use topical acyclovir ointment, spray acyclovir cream and other antiviral drug therapy. Ointment pain is more serious, you can apply topical lidocaine, benzocaine and other ointments. If secondary infection occurs later, antibiotic drugs such as mupirocin ointment need to be added. Pay attention to hygiene during treatment and keep the local skin clean. For patients with dry, cracked and blistered lips, they should go to the local regular hospital and choose the appropriate way to deal with it.